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Table of Contents
Introduction
1
Cell and Membrane Physiology
Evolution of Cells
Water
Solutes
Cell Membrane
Membrane Transport
Channels
Transporters
Pumps
Regulation of Calcium Ions
Maintenance of Cell Volume
2
Membrane Biophysics
Thermodynamics of Membrane Transport
Chemical Potential
Electrochemical Potential
Equilibrium Potential
Coupled Potentials
Diffusion
3
Membrane Potential
Electrical Components and Circuits
Equivalent Components
The RC Circuit
Recording the Membrane Potential
Membrane Potential – Equivalent Circuits
The Goldman Equation
Tutorial: RC Circuits 1
Tutorial: RC Circuits 2
4
Action Potentials
Electrically Excitable Cells
Properties of Action Potentials
Ion Channel Permeation and Selectivity
Ion Channel Gating
Changes in Sodium and Potassium Conductances
Conduction of Action Potentials along Axons
Tutorial: Action Potentials 1
5
Neurotransmitter Receptors
Classification of Neurotransmitter Receptors
Cys-loop Receptors
Glutamate Receptors
G Protein-Coupled Receptors
6
Synaptic Transmission
Basic Features of Synaptic Transmission
Sequence of Events During Synaptic Transmission
Synaptic Transmission at the Neuromuscular Junction
Excitatory Synaptic Transmission in the CNS
Inhibitory Synaptic Transmission in the CNS
Neuromodulation
7
Modeling Electrical Excitability
Passive Properties of a Small Cell
Leak Conductance and Resting Membrane Potential
Voltage-Gated Channels
Action Potential in a Small Cell
Problem Set
Appendix 1:
Techniques
Signal Processing
Appendix 2:
Numerical Methods
Numerical Methods for First Order Differential Equations
Explicit Methods
Implicit Methods
Examples and Problems
About this book
Acknowledgements, Contact, Credits and Copyright
How to use this book